Sprecher
Dr.
Vanessa Krausel
(Universitätsklinikum Münster, Medizinische Klinik D)
Beschreibung
Recessive mutations in the gene OSGEP cause Galloway-Mowat syndrome, defined by developmental brain defects and progressive glomerulosclerosis in paediatric patients. OSGEP is part of a multiprotein complex that catalyzes post-transcriptional modifications of tRNA and thereby regulates protein translation. Previous studies reported an accumulation of endoplasmic reticulum stress following OSGEP depletion; however, the exact molecular mechanisms of podocyte injury in this condition remain elusive.
Hauptautoren
Dr.
Vanessa Krausel
(Universitätsklinikum Münster, Medizinische Klinik D)
Lisanne Pund
(Universitätsklinikum Münster, Medizinische Klinik D)
Thomas Weide
(Universitätsklinikum Münster, Medizinische Klinik D)
Prof.
Hermann Pavenstädt
(Universitätsklinikum Münster, Medizinische Klinik D)
Prof.
Michael Krahn
(Universitätsklinikum Münster, Medizinische Klinik D)
Dr.
Daniela Braun
(Universitätsklinikum Münster, Medizinische Klinik D)